Infants who were born from HIV-infected women had so poor condition. They got infectious disease and sometimes killed by this infection. Why so many children who were born from HIV-infected women have poor condition?
Immunity is the most important things to answer this question. As we know HIV infects T helper cells (CD4+ T cell). This is very important in the human immune system. HIV infection leads to low levels of CD4+ T helper. As a result, cell mediated immunity is lost and it makes host more susceptible to get infections.
Pregnant women transfer their antibodies to her infant through placenta. It can give the immunity to her child for about six months. It can be very useful to protect the baby from some infections before they vaccinated. According to the study in South Africa, infected women had lower levels of specific antibody to Hib and pneumococcus than uninfected-women. Infected women also had significant reductions in placental transfer of Hib, pertussis, and tetanus – specific antibody compare with uninfected-women (Jones, 2011). So their infants will easily get infection, especially in developing country.
We should take care of this issue. Based on the study, pneumonia and pertusis vaccination during or before pregnancy of HIV-infected women may benefit both, mother and child (Jones, 2011). So, infants of HIV-infected women can be protected from this infection.
References:
Jones, Christine E. et al. 2011. Maternal HIV Infection and Antibody Responses Against Vaccine-Preventable Diseases in Uninfected Infants. JAMA. 2011;305(6):576-584.
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